Lahn Lab Publications


    2006


  • Vallender EJ, & Lahn BT.
    A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway.
    Human Molecular Genetics. 15:3034 (2006). pdf
  • Bush EB, & Lahn BT
    The evolution of word composition in metazoan promoter sequence
    PloS Comput Biol. 2(11): e150 (2006). doi:10.1371/journal.pcbi.0020150.
  • Vallender EJ*, Paschall JE*, Malcom CM, Lahn BT & Wyckoff GJ. (*Equal contributors)
    SPEED: A molecular evolution based database of mammalian orthologous groups.
    Bioinformatics. (in press).
  • Vallender TW & Lahn BT.
    Improved DNA methylation analysis via enrichment of demethylated cells expressing an X-inactivated transgene.
    BioTechniques. 41:461 (2006).pdf
  • Choi SS, Vallender EJ & Lahn BT.
    Systematically assessing the influence of three-dimensional structural context on the molecular evolution of mammalian proteomes.
    Molecular Biology and Evolution. 23:2131 (2006).pdf
  • Vallender TW & Lahn BT.
    Localized methylation in the key regulator gene endothelin-1 is associated with cell type-specific transcriptional silencing.
    FEBS Letters. 580:4560 (2006). pdf
  • Zhang JQ, Yu XB, Ma BF, Yu WH, Zhang AX, Huang G, Mao FF, Zhang XM, Wang ZC, Li SN, Lahn BT & Xiang AP.
    Neural differentiation of embryonic stem cells induced by conditioned medium from neural stem cell.
    Neuroreport. 17:981 (2006). pdf
  • Dorus S, Anderson JR, Vallender EJ, Gilbert SL, Zhang L, Chemnick LG, Ryder OA, Li W & Lahn BT.
    Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates.
    Human Molecular Genetics. 15:2031 (2006). pdf
  • Evans PD*, Vallender EJ* & Lahn BT. (*Equal contributors)
    Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ.
    Gene. 375:75 (2006). pdf
  • Ma BF, Liu XM, Xie XM, Zhang AX, Zhang JQ, Yu WH, Zhang XM, Li SN, Lahn BT & Xiang AP.
    Slower cycling of nestin-positive cells in neurosphere culture.
    Neuroreport. 17:377 (2006). pdf
  • Gilbert SL, Zhang L, Forster M, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL & Lahn BT.
    Trak1 mutation disrupts GABAA receptor homeostasis in hypertonic mice.
    Nature Genetics. 38:245 (2006). pdf pdf
  • Lahn BT& Mekel-Bobrov N.
    Evolution: Human understanding.
    Global Agenda. (2006). pdf

    • 2005


  • Bussell JJ, Pearson NM, Kanda R, Filatov DA & Lahn BT.
    Human polymorphism and human-chimpanzee divergence in pseudoautosomal region correlate with local recombination rate.
    Gene. 368:94 (2005). pdf
  • Choi SS*, Li W* & Lahn BT. (*Equal contributors)
    Robust signals of coevolution of interacting residues in mammalian proteomes identified by phylogeny-aided structural analysis.
    Nature Genetics. 37:1367 (2005). pdf pdf
  • Bush EC & Lahn BT.
    Selective constraint on noncoding regions of hominid genomes.
    PLoS Computational Biology. 1:e73 (2005). pdf
  • Choi SS, Bush EC & Lahn BT.
    Different classes of tissue-specific genes show different levels of noncoding conservation.
    Genomics. 87:433 (2005). pdf
  • Mekel-Bobrov N, Gilbert SL, Evans PD, Vallender EJ, Anderson JR, Hudson RR, Tishkoff SA & Lahn BT.
    Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.
    Science. 309:1720 (2005). pdf
  • Evans PD, Gilbert SL, Mekel-Bobrov N, Vallender EJ, Anderson JR, Tishkoff SA, Hudson RR & Lahn BT.
    Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.
    Science. 309:1717 (2005). pdf
  • Gilbert SL, Dobyns WB & Lahn BT.
    Genetic links between brain development and brain evolution.
    Nature Reviews Genetics. 6:581 (2005). pdf
  • Wyckoff GJ*, Malcom CM*, Vallender EJ* & Lahn BT. (*Equal contributors)
    A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate.
    Trends in Genetics. 21:381 (2005). pdf
  • Vallender EJ, Pearson NM & Lahn BT.
    The X chromosome: not just her brother’s keeper.
    Nature Genetics. 37:343 (2005). pdf

    • 2004


  • Gilbert SL, Ozdag F, Ulas UH, Dobyns WB & Lahn BT.
    Hereditary hyperekplexia caused by novel mutations of GLRA1 in Turkish families.
    Molecular Diagnosis. 8:151 (2004). pdf
  • Dorus S*, Vallender EJ*, Evans PD, Anderson JR, Gilbert SL, Mahowald M, Wyckoff GJ, Malcom CM & Lahn BT. (*Equal contributors)
    Accelerated evolution of nervous system genes in the origin of Homo sapiens.
    Cell. 119:1027 (2004). pdf
  • Dorus S, Evans PD, Wyckoff GJ, Choi SS & Lahn BT.
    Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity.
    Nature Genetics. 36:1326 (2004). pdf
  • Vallender EJ & Lahn BT.
    Effect of chromosomal rearrangements on human-chimpanzee molecular evolution.
    Genomics. 84:757 (2004). pdf
  • Vallender EJ & Lahn BT. Positive selection on the human genome.
    Human Molecular Genetics. 13:R245 (2004). pdf
  • Wong A, Vallender EJ, Heretis K, Ilkin Y, Lahn BT, Martin CL & Ledbetter DH. Diverse fates of paralogs following segmental duplication of telomeric genes.
    Genomics. 84:239 (2004). pdf
  • Mekel-Bobrov N & Lahn BT. Ancient DNA analysis of human remains from Tell Kurdu.
    Anatolica. 30:72 (2004). pdf
  • Evans PD, Anderson JR, Vallender EJ, Choi SS & Lahn BT.
    Reconstructing the evolutionary history of Microcephalin, a gene controlling human brain size.
    Human Molecular Genetics. 13:1139 (2004). pdf
  • Vallender EJ & Lahn BT. How mammalian sex chromosomes acquired their peculiar gene content.
    BioEssays. 26:159 (2004). pdf
  • Evans PD*, Anderson JR*, Vallender EJ, Gilbert SL, Malcom CM, Dorus S & Lahn BT. (*Equal contributors) Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.
    Human Molecular Genetics. 13:489 (2004). pdf

    • 2003


  • Choi SS & Lahn BT.
    Strong positive selection in the evolution of MRG, a neuron-specific gene family implicated in nociception.
    Genome Research. 13:2252 (2003). pdf
  • Dorus S, Gilbert SG, Forster M, Barndt RJ & Lahn BT.
    The CDY-related gene family: coordinated evolution in copy number, expression profile, and protein sequence.
    Human Molecular Genetics. 12:1643 (2003). pdf
  • Malcom C, Wyckoff GJ & Lahn BT.
    Genic mutation rates in mammals: local similarity, chromosomal heterogeneity, and X-versus-autosome disparity.
    Molecular Biology and Evolution. 20:1633 (2003). pdf
  • Dorus S, Wyckoff GJ & Lahn BT.
    Mammalian sex chromosome evolution.
    Encyclopedia of the Human Genome. (2003). pdf

    • 2002


  • Lahn BT, Tang ZL, Zhou J, Barndt RJ, Parvinen M, Allis CD & Page DC.
    Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.
    PNAS. 99:8707 (2002). pdf
  • Lahn BT.
    Stem cell research: separating eternal human drive from contemporary cultural fashion.
    Medicine on the Midway. Fall issue (2002). pdf

    • 2001


  • Lahn BT, Pearson NM & Jegalian K.
    The human Y chromosome, in the light of evolution.
    Nature Reviews Genetics. 2:207 (2001). pdf
  • Honarpour N, Gilbert SL, Lahn BT, Wang X & Herz J.
    Apaf-1 deficiency and neural tube closure defects are found in fog mice.
    PNAS. 98:9683 (2001). pdf
  • Jegalian K & Lahn BT.
    Why the Y is so weird?
    Scientific American. 282(2):56 (Feb. 2001). pdf

    • 2000 and Earlier


  • Lahn BT & Page DC.
    A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.
    Human Molecular Genetics. 9:311 (2000). pdf
  • Lahn BT & Page DC.
    Four evolutionary strata on the human X chromosome.
    Science. 286:964 (1999). pdf
  • Lahn BT & Page DC.
    Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.
    Nature Genetics. 21:429 (1999). pdf
  • Lahn BT & Jegalian K.
    The key to masculinity.
    Scientific American Presents (Special issue of Scientific American). 10(2):20 (1999). pdf
  • Lahn BT & Page DC.
    Functional coherence of the human Y chromosome.
    Science. 278:675 (1997). pdf
  • Lahn BT, Ma N, Breg WR, Stratton R, Surti U & Page DC.
    Xq-Yq interchange resulting in supernormal X-linked gene expression in severely retarded males with 46,XYq Karyotype.
    Nature Genetics. 8:243 (1994). pdf